Department of Medical Biochemistry and Microbiology

Staffan Johansson research group

Adhesion-dependent cell signalling

Adhesion of cells to specific proteins in the extracellular matrix contributes to the organization of tissues. In addition, it provides the cells with information about the surrounding environment, which is important for their migration, differentiation, and proliferation. As the main adhesion and migration receptors of cells, integrins are potential targets for regulation of several adhesion-related events of clinical relevance, such as wound healing, angiogenesis, thrombus formation, leukocyte extravasation to inflammatory sites, and tumor metastasis. Our work is focused on integrin signals involved in adhesion-dependent cell survival and proliferation